Question 1

What is CircleDNA?

Accepted Answer

CircleDNA is the world’s most comprehensive DNA test that enables you to take full control of your health by understanding your genetic blueprint, so you can make informed decisions about your health with full confidence. This at-home test provides 500+ reports about your diet, nutrition, sports, cancer and disease risks, carrier conditions and much more with a simple saliva swab. The results are delivered within 18 business days in an easy-to-use mobile app.

Question 2

What can I do if I find out I have an elevated risk of a disease/cancer?

Accepted Answer

1. Talk to a genetic counselor: They can help you understand the implications of having an increased risk of developing certain diseases or cancer. They can also guide you through your options for testing, screening, and risk reduction.2. Consider genetic testing for family members: If you have an increased risk for certain diseases or cancer, your family members may also be at risk. Genetic testing can help identify if other family members have the same mutation and are at an increased risk for these conditions.3. Develop a screening plan: If you have an increased risk of developing certain diseases or cancer, your doctor may recommend more frequent or earlier screening tests to detect them at their earliest stages when they are most treatable.4. Explore risk reduction options: Depending on the type of disease or cancer associated with your increased risk, there may be risk reduction options available, such as lifestyle changes or medical interventions.

Question 3

How does CircleDNA test for elevated risks of diseases and cancers?

Accepted Answer

For two of the clinically-oriented sections in CircleDNA, Cancer Risk and Family Planning, we screen for disease-causing mutations in genes associated with the respective diseases. If we identify any mutations, we report them as positive findings. This type of mutation is known as monogenic variant, which is a single mutation that can substantially increase the risk of disease.Another type of genetic risk assessment is called polygenic model. This type of assessment involves combining individual variants, each with a small effect, into a polygenic model to determine an individual's risk for complex diseases.These diseases can be caused by hundreds of genetic variants that act in conjunction with environmental factors. The total number of genetic variants that an individual has, known as polygenic scores, can help assess the heritable risk of developing a particular disease. The threshold of the model determines whether your score is above or below the threshold, which then determines the genetic risk.Some diseases are both monogenic and polygenic disease, such as Parkinson’s disease, Stroke, etc. For these diseases, we use both polygenic modeling and monogenic variant screening to evaluate your risk. If we identify a single monogenic mutation, we classify the genetic risk as elevated.

Question 4

How are my data and privacy protected?

Accepted Answer

CircleDNA adheres to the leading international security standard, ISO-27001, as we implement physical, technical, and administrative measures to prevent any unauthorized access to, or disclosure of, your sensitive information. All connections are encrypted with Secure Socket Layer (SSL) technology. We do not sell, lease, or rent your personal information to any third party without your explicit consent. Your data will also never be shared with anyone outside of CircleDNA for marketing or other purposes. You are the only individual or party who is able to authorize how your information is used, stored, and shared with others.

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